What Causes Parkinson’s Disease?

Parkinson's disease is caused by the death of a neuron in a part of the brain known as the substantia nigra. This area of the brain is part of a system of neurons known as the basal ganglia. This system is very important for traffic control. Neurons in the substantia nigra secrete dopamine. The diminished effect of dopamine on the basal ganglia causes Parkinson's signs and symptoms.

Anomalies also occur in the neurons of Parkinson's patients. This abnormality is called the Levy agency. These bodies are collections of abnormal proteins that gather into reddish-pink masses in the cytoplasm of substantia nigra neurons. However, the persons who are most at risk of developing Parkinson's disease and suffer from paraquat over a long period of time they are eligible to make a claim by filing a paraquat lawsuit from www.paraquatparkinsonslawsuit.com/

Parkinson's disease 'may' start in gut - BBC News

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Unfortunately, it's not known what causes most Parkinson's disease. However, the causes are known, almost all of which involve damage to the substantia nigra. Toxins such as carbon disulfide and some street drugs are known to kill dopamine-secreting neurons, which cause Parkinson's disease. 

Another toxin known as MPTP, which was accidentally created by chemists trying to make a synthetic derivative of heroin illegally, is highly toxic to the substantia nigra cells. It causes incurable Parkinson's disease in those unfortunate enough to swallow it.

However, not much is known about the genetics of Parkinson's disease. There appear to be a number of genetic causes for the disease. One gene mutation includes a-synuclein, a protein that is a major ingredient of Lewy bodies. Other genetic deviations can also perform a role in Parkinson's, but only make a small contribution to the overall.